Mechanical ventilation and disuse atrophy of the diaphragm.

Mechanical Ventilation and Disuse Atrophy of the Diaphragm

Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans.

BACKGROUND The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the same may also occur in the human diaphragm. METHODS We obtained biopsy specimens from the costal diaphragms of 14 brain-dead organ donors before organ harvest (case subjects) and compared them with intraoperati...

REVIEWS Intracellular Signal for Skeletal Muscle Adaptation Mitochondrial signaling contributes to disuse muscle atrophy

Powers SK, Wiggs MP, Duarte JA, Zergeroglu AM, Demirel HA. Mitochondrial signaling contributes to disuse muscle atrophy. Am J Physiol Endocrinol Metab 303: E31–E39, 2012. First published March 6, 2012; doi:10.1152/ajpendo.00609.2011.—It is well established that long durations of bed rest, limb immobilization, or reduced activity in respiratory muscles during mechanical ventilation results in sk...

Toll-like receptor 4 signaling in ventilator-induced diaphragm atrophy.

BACKGROUND Mechanical ventilation induces diaphragm muscle atrophy, which plays a key role in difficult weaning from mechanical ventilation. The signaling pathways involved in ventilator-induced diaphragm atrophy are poorly understood. The current study investigated the role of Toll-like receptor 4 signaling in the development of ventilator-induced diaphragm atrophy. METHODS Unventilated anim...

Mitochondrial signaling contributes to disuse muscle atrophy.

It is well established that long durations of bed rest, limb immobilization, or reduced activity in respiratory muscles during mechanical ventilation results in skeletal muscle atrophy in humans and other animals. The idea that mitochondrial damage/dysfunction contributes to disuse muscle atrophy originated over 40 years ago. These early studies were largely descriptive and did not provide uneq...